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Updated: Nov 4, 2025

Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
Intestinal adaptation in fluid restricted cardiac failure following extensive bowel resection
M Jothinathan1, Y Y Gan2, A Qayyum3
1Sarawak General Hospital, Department of Surgery, Sarawak, Malaysia. jothinathan84@gmail.com.
Abstract:
Acute mesenteric ischemia (AMI) is an emergency associated with a high mortality rate. A high index of clinical suspicion, prompt diagnosis and treatment is necessary to improve the patient outcome. The principle of damage control surgery should be adopted in the management of critically ill surgical patients with AMI. Strategic planning by resecting the ischemic bowel, physiological restoration and planned reassessment of remnant bowel with a definitive procedure is recommended. The resection of a long segment ischemic bowel may result in morbidity such as that of short bowel syndrome. We report here a case of decompensated cardiac failure in a 56-year-old lady, presented with one-day history of severe acute epigastric pain and abdominal distension. She presented with extensive bowel ischemia involving most of the superior mesenteric artery distribution. Damage control surgery followed by entero-colic anastomosis was performed 48 hours later. The patient recovered with remarkable intestinal adaptation without exhibiting short bowel syndrome symptoms despite the postulated theory of altered intestinal permeability in decompensated cardiac failure.
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