Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

63.5K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
63.5K
The Pituitary Gland01:17

The Pituitary Gland

8.2K
The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.
8.2K
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

1.1K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinicopathologic Analysis of 43 Surgically Resected Lactotroph Pituitary Neuroendocrine Tumors Stratified by Surgical Indication: A Pathologic Reappraisal of Apparent Male Aggressiveness.

The American journal of surgical pathology·2026
Same author

Compressive stress inhibits proliferation in AsPC-1 pancreatic cancer cells and reduction of Myc protein.

PloS one·2026
Same author

Possible involvement of the mesenchymal cell marker Meflin in regeneration after retinal injury.

Scientific reports·2026
Same author

CCL5 enhances invasion of squamous cell carcinoma via syndecan-1-dependent ERK signaling.

Cell structure and function·2026
Same author

Meflin confers antifibrotic properties to intestinal fibroblasts in inflammatory bowel disease.

The Journal of clinical investigation·2026
Same author

Differential roles of ATM and Chk2 in cold atmospheric helium plasma-induced cell death in Molt-4 human leukemia cell with intact or reduced p53 expression.

Biochemical and biophysical research communications·2026

Related Experiment Video

Updated: Nov 4, 2025

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

782

A new primate model of hypophyseal dysfunction.

Teppei Kawabata1, Hidetaka Suga2, Kazuhito Takeuchi1

  • 1Department of Neurosurgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan.

Scientific Reports
|May 25, 2021
PubMed
Summary
This summary is machine-generated.

Researchers developed a safer surgical technique to create a pituitary dysfunction model in monkeys for regenerative medicine. This hypophysectomy protocol ensures long-term survival through hormone replacement therapy, enabling future preclinical studies.

More Related Videos

Author Spotlight: Hypothalamic Neural Mechanism Insights
09:29

Author Spotlight: Hypothalamic Neural Mechanism Insights

Published on: August 4, 2023

4.2K
Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

12.7K

Related Experiment Videos

Last Updated: Nov 4, 2025

Developing a Rat Model for Bipolar Disorder
04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

782
Author Spotlight: Hypothalamic Neural Mechanism Insights
09:29

Author Spotlight: Hypothalamic Neural Mechanism Insights

Published on: August 4, 2023

4.2K
Assessing Activity-based Anorexia in Mice
08:26

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

12.7K

Area of Science:

  • Primate models
  • Endocrinology
  • Regenerative medicine

Background:

  • Preclinical studies for pituitary regenerative medicine require a reliable hypophyseal model in non-human primates.
  • Previous hypophysectomy techniques in monkeys were associated with safety and satisfaction concerns.

Purpose of the Study:

  • To establish a hypophyseal dysfunction model in a cynomolgus monkey using a safer surgical approach.
  • To develop a protocol for pituitary hormone replacement therapy in this primate model.

Main Methods:

  • Endoscopic transoral transsphenoidal surgery with navigation support was employed for pituitary gland resection in a cynomolgus monkey.
  • Total pituitary removal was confirmed via pathological examination and computed tomography.
  • Endocrinological examinations and stimulation tests were used to verify hypopituitarism.

Main Results:

  • The minimally invasive surgical technique facilitated complete pituitary gland removal without complications like cerebrospinal fluid leakage.
  • Endocrinological assessments confirmed induced hypopituitarism.
  • Postoperative hormone replacement therapy ensured the monkey's long-term survival.

Conclusions:

  • A safe and effective surgical method for creating a hypophyseal dysfunction model in cynomolgus monkeys was successfully established.
  • The developed protocol, including hormone replacement therapy, supports the use of this model for future preclinical research in pituitary regenerative medicine.