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Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
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Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

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Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19

Alec A Schmaier, Gabriel Pajares Hurtado, Zachary J Manickas-Hill

    Medrxiv : the Preprint Server for Health Sciences
    |May 25, 2021
    PubMed
    Summary

    Severe COVID-19 causes endothelial dysfunction and thrombosis by disrupting the Tie2-angiopoietin axis. Activating Tie2 with AKB-9778 reversed these prothrombotic changes, suggesting a therapeutic approach for COVID-19 patients.

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