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Updated: Nov 4, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

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Association between anti-complement factor H antibodies and renal outcome in primary membranous nephropathy

Yu Kagaya, Norifumi Hayashi, Keiji Fujimoto

    Clinical Nephrology
    |May 25, 2021
    PubMed

    Insights

    Elevated anti-complement factor H (CFH) antibodies are prevalent in primary membranous nephropathy (MN) patients. Higher anti-CFH antibody levels independently predict worse kidney function in MN.

    Area of Science:

    • Nephrology
    • Immunology
    • Complement System

    Background:

    • Complement factor H (CFH) regulates the alternative complement pathway.
    • The role of anti-CFH antibodies in primary membranous nephropathy (MN) is not well understood.

    Purpose of the Study:

    • To investigate the prevalence of anti-CFH antibodies in primary MN patients.
    • To determine the association between anti-CFH antibodies and clinical outcomes in MN.

    Main Methods:

    • Retrospective study of 106 kidney disease patients (36 primary MN) and 18 healthy controls.
    • Serum anti-CFH antibody titers measured using enzyme-linked immunosorbent assay (ELISA).
    • Cox proportional hazards analysis used to assess predictors of renal dysfunction.

    Main Results:

    • Anti-CFH antibodies were detected in 77.8% of primary MN patients, significantly higher than controls.
    • Median anti-CFH antibody titers were significantly elevated in MN patients compared to all control groups.
    • Anti-CFH antibody titer was an independent predictor of unfavorable renal function.

    Conclusions:

    • Anti-CFH antibodies are frequently present in primary MN.
    • These antibodies may contribute to the worsening of kidney function in primary MN patients.
    Abstract

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