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Bone marrow biopsy in multiple myeloma: a clinical pathological study
1Institute of Hematology and Blood Bank, Lady Davis Carmel Hospital, Haifa, Israel.
Israel Journal of Medical Sciences
|June 1, 1988
Summary
Bone marrow biopsy findings in multiple myeloma correlate with patient health. Nodular patterns and lymphoid nodules are particularly linked to lower hemoglobin and fewer bone lesions, suggesting their importance in reporting.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Multiple myeloma is a hematologic malignancy characterized by abnormal plasma cells.
- Accurate assessment of disease status is crucial for patient management and prognosis.
- Bone marrow examination is a key diagnostic and monitoring tool.
Purpose of the Study:
- To investigate the correlation between bone marrow findings and clinical parameters in multiple myeloma patients.
- To determine if specific histological features beyond plasma cell percentage predict clinical status.
Main Methods:
- Review of 42 bone marrow aspirates and biopsies from multiple myeloma patients.
- Cross-tabulation of plasma cell percentage, cytological immaturity, infiltration patterns, lymphoid nodules, and fibrosis with clinical parameters (hemoglobin, osteolytic lesions, renal function).
Main Results:
- Higher plasma cell percentage (>70%) correlated with lower hemoglobin levels (<10 g/dl).
- Nodular histological patterns and lymphoid nodules showed stronger correlations with reduced hemoglobin and renal impairment (creatinine >2 mg/dl) than plasma cell number.
- Lymphoid nodules were associated with fewer osteolytic bone lesions.
- Fibrosis and plasma cell immaturity did not correlate with clinical parameters.
Conclusions:
- Bone marrow biopsy reports for multiple myeloma should include plasma cell infiltration patterns and the presence of lymphoid nodules, in addition to plasma cell percentage.
- These histological features may offer valuable prognostic information beyond plasma cell burden.