The Human Salivary Proteome Wiki: A Community-Driven Research Platform
W W Lau1,2, M Hardt3,4, Y H Zhang5
1Office of Intramural Research, Center for Information Technology, National Institutes of Health, Bethesda, MD, USA.
Journal of Dental Research
|May 25, 2021
Summary
The Human Salivary Proteome (HSP) Wiki is a new public database for saliva proteome research. It centralizes and updates information on saliva composition for health and disease studies.
Area of Science:
- Biochemistry
- Bioinformatics
- Genomics
Background:
- Saliva is a valuable fluid for monitoring oral and systemic health.
- A centralized, updated platform for salivary proteome data is needed.
- Existing data is fragmented across various databases.
Purpose of the Study:
- To introduce the Human Salivary Proteome (HSP) Wiki, a public data platform.
- To provide a centralized resource for curated salivary proteome data and knowledge.
- To facilitate research and retrieval of information on the saliva proteome.
Main Methods:
- Dynamically compiled and updated based on published studies and protein records.
- Integrated data from external protein, genome, transcriptome, and glycome databases.
- Incorporated data from human disease-related studies.
Main Results:
- Developed the HSP Wiki, a user-friendly interface for exploring saliva proteome data.
- Enabled browsing, querying, data comparison, and annotation of protein entries.
- Ensured data quality through user feedback and curator review.
Conclusions:
- The HSP Wiki advances knowledge of saliva composition and function in health and disease.
- It serves as a global platform for exchanging salivary proteome information and fostering collaboration.
- It will aid in the diagnosis, prediction, and therapy of diseases using salivary biomarkers.
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