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Psychotropic Drugs and the Microbiome.
Sofia Cussotto1, Gerard Clarke2, Timothy G Dinan2
1Department of Anatomy and Neuroscience, APC Microbiome Ireland, University College Cork, Cork, Ireland.
Modern Trends in Psychiatry
|May 25, 2021
Summary
The gut microbiome influences how psychotropic drugs work. Understanding this interaction is crucial for developing new psychiatric medications targeting the microbiome.
Area of Science:
- Microbiology
- Pharmacology
- Neuroscience
Background:
- The human gut microbiome is integral to host physiology, influencing health and disease.
- Bidirectional interactions between medications and the gut microbiome are increasingly recognized.
Purpose of the Study:
- To review how drugs impact gut microbiome composition.
- To examine the microbiome's influence on psychotropic medication pharmacodynamics and pharmacokinetics.
Main Methods:
- Literature review of in vivo and in vitro studies.
- Analysis of effects across various psychotropic drug classes.
Main Results:
- Drugs demonstrably alter gut microbiome composition.
- The microbiome affects the efficacy and metabolism of psychotropic medications.
Conclusions:
- The gut microbiome is a significant factor in psychotropic drug action.
- Future psychiatric drug discovery must consider the microbiome as a therapeutic target.
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