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The impact of COVID-19 on familial Mediterranean fever: a nationwide study

Zafer Günendi1, Fatma Gül Yurdakul2, Hatice Bodur3

  • 1Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Gazi University, Ankara, Turkey.

Rheumatology International
|May 25, 2021
PubMed

Insights

Familial Mediterranean fever (FMF) patients generally experienced mild coronavirus disease 2019 (COVID-19). FMF characteristics did not appear to increase the risk of severe COVID-19 outcomes like hospitalization.

Area of Science:

  • Rheumatology
  • Infectious Diseases
  • Genetics

Background:

  • Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder.
  • The impact of FMF on coronavirus disease 2019 (COVID-19) susceptibility and severity is not well understood.

Purpose of the Study:

  • To evaluate the impact of COVID-19 in patients with FMF.
  • To assess the relationship between FMF characteristics and severe COVID-19 outcomes.

Main Methods:

  • A national network of 21 centers collected data on 822 FMF patients.
  • Demographics, FMF clinical/genetic data, and COVID-19 outcomes were analyzed.

Main Results:

  • Seven percent of FMF patients (59/822) were diagnosed with COVID-19, mostly with mild to moderate disease.
  • Hospitalized COVID-19 patients with FMF were older; other FMF characteristics showed no association with poor outcomes.
  • Complications included thromboembolism and acute respiratory distress syndrome in two patients.

Conclusions:

  • FMF itself may not be a significant risk factor for severe COVID-19 outcomes.
  • Colchicine compliance and resistance were noted in a subset of FMF patients with COVID-19.

Keywords:
COVID-19ColchicineFamilial Mediterranean feverHospitalizationPoor outcomesRheumatic diseases

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