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Biochemical Measurement of Neonatal Hypoxia
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Biochemical predictors for metabolic syndrome in preterm infants according to weight ratio

Claudia Silveira Viera1, Grasiely Masotti Scalabrin Barreto2, Rita de Cassia Silveira3

  • 1Universidade Estadual do Oeste do Paraná, Cascavel, PR, Brasil, clausviera@gmail.com.

Archives of Endocrinology and Metabolism
|May 25, 2021
PubMed

Insights

Preterm infants

Area of Science:

  • Neonatal Medicine
  • Pediatric Cardiology
  • Metabolic Disorders

Background:

  • Prematurity and low birth weight are risk factors for adult cardiovascular disease.
  • The metabolic profile of preterm infants may be influenced by birth weight relative to gestational age (GA).

Purpose of the Study:

  • To investigate the correlation between birth weight adequacy and the metabolic profile of preterm infants from birth to six months corrected age.
  • To assess if the relationship between birth weight and GA impacts metabolic markers in preterm infants.

Main Methods:

  • A longitudinal, prospective study of 70 preterm and 54 term infants.
  • Infants were categorized as Appropriate for GA (AGA) or Small for GA (SGA).
  • Metabolic markers (cholesterol, glucose, triglycerides, insulin) and anthropometry were tracked at birth, NICU discharge, and six months corrected age.

Main Results:

  • No significant differences in most biochemical tests between AGA and SGA groups.
  • The SGA group showed a significant increase in triglyceride levels above age-appropriate reference values during follow-up.

Conclusions:

  • Metabolic profile changes in preterm infants do not correlate with birth weight adequacy.
  • Continuous monitoring of lipid profiles in preterm infants is crucial due to elevated long-term cardiovascular risk.
Abstract

Keywords:
Premature infantlongitudinal studieslow birth weight infantmetabolic syndrome

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