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Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.

Cancers Originate from Somatic Mutations in a Single Cell

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Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study

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Authorship Patterns in Cancer Genomics Publications Across Africa.

Solomon O Rotimi^1,2, Oluwakemi A Rotimi^1,2, Bodour Salhia^1,3

¹Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA.

JCO Global Oncology

|May 25, 2021

Summary

Cancer genomics research on African populations is scarce, with most authorship from North Africa. Concerted efforts are needed to boost African research capacity and achieve global cancer equity.

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Area of Science:

Genomics
Oncology
Public Health

Background:

Authorship patterns reflect research capacity, crucial for tailoring cancer control in Africa.
Cancer mortality in Africa is rising, yet African populations are underrepresented in cancer genomics studies.

Purpose of the Study:

To analyze authorship patterns in cancer genomics research concerning African populations.
To identify research capacity and representation across African countries in this field.

Main Methods:

PubMed metadata from 1990-2019 on African cancer genomics publications were analyzed.
R packages RISmed and Pubmed.mineR were used to examine authorship affiliation.

Main Results:

Only 0.016% of global cancer publications focused on African cancer genomics.
North African countries (Tunisia, Morocco, Egypt, Algeria) dominated authorship (>50%).
Sub-Saharan Africa (South Africa, Nigeria) and the US had limited representation; nearly 50% of African nations had no contributing authors.

Conclusions:

A significant paucity of cancer genomics research exists for African populations and by African authors.
There is a critical need for increased research capacity and collaboration within Africa.
Enhancing African research is essential for global equity in cancer outcomes.