CRISPR/Cas9 in cancer: An attempt to the present trends and future prospects

Area of Science:

• Oncology
• Genetics
• Molecular Biology

Background:

• Cancer, a leading global cause of death, involves genetic and epigenetic changes driving tumor formation and metastasis.
• While cancer genomics is advancing, the functional roles of many mutated genes remain unclear.
• CRISPR/Cas9 technology has emerged as a powerful tool for precise genome editing across various organisms.

Purpose of the Study:

• To review the historical development and applications of CRISPR/Cas9 technology.
• To highlight the role of CRISPR/Cas9 in cancer cell genome editing for understanding tumorigenesis.
• To discuss the therapeutic potential of CRISPR/Cas9 in cancer treatment.

Main Methods:

• Literature review focusing on CRISPR/Cas9 applications in cancer research.
• Analysis of studies investigating CRISPR/Cas9 mechanisms in tumorigenesis.
• Examination of research utilizing animal models for CRISPR/Cas9-based cancer therapeutics.

Main Results:

• CRISPR/Cas9 enables functional studies of cancer-associated genes and pathways.
• The technology facilitates the development of novel cancer models and therapeutic strategies.
• Recent research demonstrates the potential of CRISPR/Cas9 in targeted cancer treatments.

Conclusions:

• CRISPR/Cas9 is a transformative technology for dissecting cancer biology and advancing therapeutic interventions.
• Continued research into CRISPR/Cas9 mechanisms and applications holds significant promise for future cancer care.
• Addressing current challenges and exploring future trends in CRISPR/Cas9 research is crucial for its clinical translation.