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The synthesis of 2-(functionalized methyl)-1 beta-methylcarbapenems

S M Schmitt¹, T N Salzmann, D H Shih

¹Merck Sharp and Dohme Research Laboratories, Rahway, New Jersey 07065.

The Journal of Antibiotics

|June 1, 1988

Abstract:

The synthesis of 1 beta-methylcarbapenems having a ROCH2 substituent at the 2-position is described. Their in vitro antibacterial activity and DHP-I susceptibilities are presented.

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