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Updated: Nov 4, 2025
Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
Published on: March 1, 2013
Progresses in polymeric nanoparticles for delivery of tyrosine kinase inhibitors
Behrouz Foroughi-Nia1, Jaleh Barar2, Mohammad Yousef Memar3
1Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract:
Tyrosine kinase inhibitors (TKIs), as an important class of chemotherapeutic drugs, induce apoptosis by altering the path of the cellular signal, resulting in cell death. However, some chemotherapeutic drugs have a limited therapeutic index and are usually destructive as well as unpredictable. In addition, the limitation of early diagnosis and inefficiency of some of the drugs in ordinary treatments lead to disease progression and decreases in the survival of cancer patients. For this purpose, various methods have been proposed, among them, nanomedicine has transpired as a modern approach for the treatment of multiple cancers. Over the last two decades, targeted therapy has been developed for cancer-specific cells/tissues and has rather restricted nonselective toxicities. In vivo and in vitro studies demonstrated nanoparticles (NPs), nano-scale drugs, and nano-carriers alone or in combination with other therapeutic, imaging, and theranostic agents would be applied as an effective approach targeting a diversity of malignant tissue. Therefore, using the latest advances in materials science and biomaterials, biology, it has happened that general diagnosis and treatment can be performed. In this review, we indicated the applications of theranostic nano-polymer and nano-liposome to TKIs delivery.
Insights
This review explores nanomedicine
Area of Science:
- Oncology
- Materials Science
- Nanomedicine
Background:
- Chemotherapeutic drugs like tyrosine kinase inhibitors (TKIs) induce apoptosis but have limitations including narrow therapeutic index and unpredictable toxicity.
- Inefficiency of conventional treatments and delayed diagnosis contribute to cancer progression and reduced patient survival.
- Nanomedicine offers a modern approach to cancer treatment, with targeted therapies developed to minimize non-selective toxicities.
Purpose of the Study:
- To review the applications of nanomedicine in cancer therapy, focusing on targeted delivery of tyrosine kinase inhibitors (TKIs).
- To highlight the potential of theranostic nanocarriers for improved cancer diagnosis and treatment.
Main Methods:
- Review of in vivo and in vitro studies on nanoparticles (NPs) and nano-carriers for cancer treatment.
- Focus on the application of theranostic nanopolymers and nanoliposomes for delivering TKIs.
- Integration of advances in materials science, biomaterials, and biology for diagnosis and treatment.
Main Results:
- Nanoparticles, nano-drugs, and nano-carriers show promise as effective agents for targeting various malignant tissues.
- Theranostic agents, alone or in combination, can be utilized for both imaging and therapeutic purposes in cancer.
- Specific focus on theranostic nano-polymers and nano-liposomes for enhanced TKI delivery.
Conclusions:
- Nanomedicine, particularly theranostic nanocarriers, presents a promising strategy for targeted cancer therapy.
- The use of nano-polymers and nano-liposomes can improve the delivery and efficacy of tyrosine kinase inhibitors.
- Advancements in materials science and biology are crucial for developing integrated diagnostic and therapeutic approaches in oncology.
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