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Related Experiment Videos

Respiratory pattern changes produced by intercostal muscle/rib vibration.

D C Bolser1, B G Lindsey, R Shannon

  • 1Department of Physiology and Biophysics, College of Medicine, University of South Florida, Tampa 33612.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|June 1, 1988
PubMed
Summary

Large-amplitude intercostal muscle/rib vibration inhibits inspiratory motor output. Costovertebral joint receptors, not just tendon organs, contribute to this effect, influencing respiratory frequency based on vagal input.

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Area of Science:

  • Respiratory Physiology
  • Neuroscience
  • Biomechanics

Background:

  • Intercostal muscle/rib vibration (IMV) inhibits inspiratory motor output, partly via tendon organ stimulation.
  • IMV can alter respiratory frequency, with varied responses reported.
  • The role of other mechanoreceptors in this response is unclear.

Purpose of the Study:

  • To investigate the contribution of costovertebral joint mechanoreceptors (CVJR's) to the inhibitory effects of IMV.
  • To elucidate the mechanisms behind varying respiratory frequency responses to IMV.

Main Methods:

  • Phrenic nerve activity was monitored in paralyzed, artificially ventilated cats and rats.
  • Intercostal spaces were vibrated at high amplitudes (125 Hz, >1,200 micron).
  • Mechanoreceptors were denervated sequentially (intercostal muscles, then CVJR's) to assess their roles.

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Main Results:

  • Vibration-induced phrenic activity reduction persisted after intercostal muscle denervation but was abolished after CVJR denervation.
  • Respiratory frequency decreased with T5/T7 vibration in vagotomized cats.
  • Respiratory frequency increased with IMV in vagal intact cats.

Conclusions:

  • Costovertebral joint mechanoreceptors (CVJR's) contribute to the inhibitory effect of IMV on inspiratory activity.
  • Pulmonary vagal afferents determine whether IMV increases or decreases respiratory frequency.
  • Anesthetics did not affect these observed responses.