Related Experiment Video

Updated: Nov 4, 2025

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
04:56

Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients

Published on: August 4, 2023

954

Preliminary study of microparticle coagulation properties in septic patients with disseminated intravascular

Shishuai Meng1, Kai Kang1, Dongsheng Fei1

  • 1Department of Intensive Care Unit, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China.

The Journal of International Medical Research
|May 26, 2021
PubMed
Abstract

Insights

In sepsis with disseminated intravascular coagulation (DIC), lower circulating microparticle (MP) levels correlate with clotting factor consumption. Tissue factor-bearing MP (TF+-MP) activity may not be the primary driver of coagulation in these patients.

Area of Science:

  • Hematology
  • Critical Care Medicine
  • Pathophysiology

Background:

  • Sepsis frequently triggers hypercoagulation and microthrombus formation.
  • Microparticles (MPs) are known to promote coagulation and pro-coagulant activity.
  • Investigating the role of MPs and tissue factor-bearing MPs (TF+-MPs) in septic disseminated intravascular coagulation (DIC) is crucial.

Purpose of the Study:

  • To determine the relationship between circulating MP levels, TF+-MP activity, and coagulation status in patients with septic DIC.
  • To compare MP levels and TF+-MP activity between septic DIC patients and healthy controls.

Main Methods:

  • Studied 30 patients with septic DIC and 30 healthy controls.
  • Measured circulating MP concentrations, TF+-MP activity (via factor Xa generation), clotting factor activity, antithrombin, soluble thrombomodulin, and serum tissue factor pathway inhibitor (TFPI).
  • Collected blood samples at multiple time points and recorded DIC and SOFA scores.

Main Results:

  • Patients with septic DIC exhibited lower circulating MP levels compared to healthy controls.
  • Circulating MP levels positively correlated with DIC scores and negatively with coagulation factors.
  • TF+-MP activity did not show a correlation with clotting factor levels or TFPI.

Conclusions:

  • Circulating MP levels play a significant role in coagulation activation and clotting factor consumption in septic DIC.
  • TF+-MP activity might not represent the predominant form of active tissue factor in septic DIC.
  • Further research is needed to elucidate the precise mechanisms of MP involvement in septic coagulopathy.
Keywords:
Coagulation factorcirculating microparticledisseminated intravascular coagulationsepsisthrombomodulintissue factor pathway inhibitortissue factor-bearing microparticle activity

More Related Videos

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.0K
Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

9.6K

Related Concept Videos

Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
547