Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study
Federica Ribaldi1,2, Christian Chicherio3,4, Daniele Altomare5,3
1Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland. federica.ribaldi@unige.ch.
Alzheimer'S Research & Therapy
|May 26, 2021
Summary
The COSCODE study investigates subjective cognitive decline (SCD) by examining metacognition, brain connectivity, and biomarkers to differentiate causes like Alzheimer's disease (AD) and psychiatric conditions.
Area of Science:
- Neuroscience
- Cognitive Science
- Medical Research
Background:
- Subjective cognitive decline (SCD) is the perceived decline in cognitive function without objective evidence.
- SCD can be an early sign of neurodegenerative diseases like Alzheimer's disease (AD), psychiatric conditions, or other comorbidities.
- The exact causes of SCD are not fully understood, but metacognition and brain connectivity may offer clues.
Purpose of the Study:
- To identify distinct profiles of metacognition, brain connectivity, behavior, and biomarkers in individuals with SCD.
- To differentiate the underlying etiologies of SCD, including incipient AD and psychiatric disorders.
- To lay the groundwork for developing risk assessment and prevention strategies for SCD.
Main Methods:
- An observational, longitudinal cohort study (COSCODE) involving 120 SCD participants and 80 controls.
- Utilizing diffusion and functional MRI, alongside behavioral and biomarker assessments at multiple time points.
- Employing both hypothesis-driven and data-driven cluster analysis to identify SCD subtypes.
Main Results:
- The study aims to define and interpret the constellation of signs and symptoms associated with different SCD etiologies.
- Analysis will focus on differentiating SCD subtypes based on metacognitive judgments, brain connectivity patterns, and biomarker profiles.
- Expected outcomes include identifying specific markers for conditions like early AD versus psychiatric disorders.
Conclusions:
- The COSCODE study is designed to elucidate the diverse causes of subjective cognitive decline.
- Findings will contribute to a better understanding of SCD, distinguishing between neurodegenerative and psychiatric origins.
- This research aims to facilitate the development of targeted risk assessment and prevention protocols for SCD.
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