Related Experiment Video
Updated: Nov 4, 2025
12:22
The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
33.8K
Papillary renal cell carcinoma: Review
Neil Mendhiratta1, Peter Muraki1, Anthony E Sisk2
1Department of Urology, University of California Los Angeles, Los Angeles, CA.
Urologic Oncology
|May 26, 2021
Summary
This review covers papillary renal cell carcinoma, a common kidney cancer subtype. It details the latest clinical, genetic, and management insights for this rising malignancy.
Area of Science:
- Oncology
- Nephrology
- Genetics
Background:
- Kidney cancer incidence is increasing globally, ranking as the 13th most common malignancy.
- Papillary renal cell carcinoma (PRCC) is the second most frequent subtype, accounting for 10-15% of renal cell carcinomas.
- Recent advancements have significantly improved our understanding of PRCC's molecular and genetic landscape.
Purpose of the Study:
- To provide a comprehensive overview of papillary renal cell carcinoma.
- To synthesize current knowledge on clinical, morphologic, radiographic, and genetic features.
- To discuss management strategies and prognosis for PRCC.
Main Methods:
- Literature review of contemporary research on papillary renal cell carcinoma.
- Synthesis of information regarding clinical presentation, imaging, and histology.
- Analysis of genetic alterations and molecular pathways implicated in PRCC.
Main Results:
- Papillary renal cell carcinoma exhibits diverse clinical and radiographic findings.
- Histologic classification is crucial for diagnosis and prognosis.
- Key genetic mutations and molecular alterations have been identified, impacting disease behavior.
Conclusions:
- A multidisciplinary approach is essential for optimal PRCC management.
- Emerging therapies target specific molecular pathways in PRCC.
- Continued research is vital to improve outcomes for patients with kidney cancer.
More Related Videos
Related Concept Videos
01:20Renal Corpuscle
4.8K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
4.8K
01:20The Retinoblastoma Gene
4.3K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.3K