Related Experiment Video

Updated: Nov 4, 2025

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method

Published on: October 7, 2025

93

MicroRNA-1: Diverse role of a small player in multiple cancers

Parvez Khan1, Nivetha Sarah Ebenezer1, Jawed Akhtar Siddiqui1

  • 1Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Seminars in Cell & Developmental Biology
|May 26, 2021
PubMed

Insights

MicroRNA-1 (miR-1) functions as a tumor suppressor, regulating cancer hallmarks like proliferation and metastasis. Its downregulation in many cancers highlights its therapeutic potential in developing novel anticancer treatments.

Area of Science:

  • Cancer Biology
  • Molecular Oncology
  • Noncoding RNA Research

Background:

  • Cancer development involves complex genetic and non-genetic variations.
  • Noncoding RNAs, including microRNAs (miRNAs), play crucial roles in cancer pathways.
  • MicroRNA-1 (miR-1) is a conserved miRNA involved in muscle development and acts as a tumor suppressor.

Purpose of the Study:

  • To review the antitumorigenic and therapeutic aspects of miR-1 in cancer.
  • To elucidate how miR-1 regulates tumor development and immunomodulatory functions.
  • To highlight the potential of miR-1 as a therapeutic agent against various cancers.

Main Methods:

  • Review of existing literature on miR-1 in cancer biology.
  • Analysis of studies demonstrating miR-1's role in cancer hallmarks.
  • Examination of miR-1's impact on proliferation, metastasis, apoptosis, angiogenesis, and immune modulation.

Main Results:

  • Downregulation of miR-1 is observed in numerous cancers (lung, breast, liver, prostate, colorectal, pancreatic, medulloblastoma, gastric).
  • miR-1 influences key cancer hallmarks, including proliferation, invasion, metastasis, apoptosis, angiogenesis, chemosensitization, and immune modulation.
  • miR-1 exhibits significant antitumorigenic properties and immunomodulatory functions.

Conclusions:

  • miR-1 acts as a potent tumor suppressor across various cancer types.
  • Restoration or modulation of miR-1 levels holds promise for novel anticancer therapies.
  • miR-1's multifaceted roles in cancer present a promising avenue for therapeutic intervention.
Keywords:
Cancer therapeuticsChemosensitivityImmunoregulationMiR-1MiRNAs

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