Infection-associated biofilms and statins: protocol for systematic review

Area of Science:

• Microbiology
• Pharmacology
• Infectious Diseases

Background:

• Biofilms are microbial communities frequently associated with persistent infections.
• Statins, widely used for cardiovascular disease prevention, show potential in preventing biofilm-associated infections.
• The precise relationship between statin use and biofilm infections requires further elucidation.

Purpose of the Study:

• To systematically review and assess the association between statin use and biofilm-associated infections.
• To explore the potential of statins as a novel therapeutic strategy against antibiotic-resistant infections.
• To inform clinical practice and future research directions in managing biofilm infections.

Main Methods:

• A comprehensive systematic review protocol was established, searching six major databases.
• Searches were conducted from inception to August 20, 2020, with no limits imposed.
• Screening, data extraction, and quality assessment (Cochrane Risk of Bias) were performed by independent reviewers.

Main Results:

• Conflicting evidence currently exists regarding the effect of statins on biofilm-associated infections.
• A meta-analysis will be considered if sufficient quantitative data are available across studies.
• Publication bias will be assessed to ensure the robustness of the findings.

Conclusions:

• Understanding the statin-biofilm association is crucial, particularly with rising antibiotic resistance.
• This review aims to provide clarity on statin efficacy against biofilm infections.
• Findings will guide future therapeutic strategies and clinical decision-making.