Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

5.7K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
5.7K
Antimicrobial Proteins01:23

Antimicrobial Proteins

11.7K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
11.7K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.2K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.2K
Controls in Experiments01:13

Controls in Experiments

14.3K
When conducting an experiment, it is crucial to have control to reduce bias and accurately measure the dependent variables. It also marks the results more reliable. Controls are elements in an experiment that have the same characteristics as the treatment groups but are not affected by the independent variable. By sorting these data into control and experimental conditions, the relationship between the dependent and independent variables can be drawn. A randomized experiment always includes a...
14.3K
Humoral Immune Responses01:36

Humoral Immune Responses

79.2K
Overview
79.2K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.7K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polyphosphates Attenuate Interleukin-12 Production in Macrophages Infected With Legionella pneumophila.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same author

Proton-activated chloride channel 1 is essential for innate host defense against bacterial sepsis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Proton-Activated Chloride Channel 1 (PACC1) is essential for innate host defense against bacterial sepsis.

bioRxiv : the preprint server for biology·2026
Same author

Reply to Chong et al.: Investigating TGFβ1 biological activities using genetically engineered mouse strains.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

The complement system: A key player in the host response to infections.

European journal of immunology·2024
Same author

Myeloid cell-derived interleukin-6 induces vascular dysfunction and vascular and systemic inflammation.

European heart journal open·2024
Same journal

Evolution and development of innate immune memory.

Science immunology·2026
Same journal

The evolving biology of T cell memory: A dynamic continuum of function and persistence.

Science immunology·2026
Same journal

Memories that endure.

Science immunology·2026
Same journal

ILC2s shoot 4 making 13s.

Science immunology·2026
Same journal

Molecular and tissue regulation of memory B cells.

Science immunology·2026
Same journal

A breath of fresh AIR in novel CAR T cell design.

Science immunology·2026
See all related articles

Related Experiment Video

Updated: Nov 4, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
05:23

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

Published on: December 23, 2020

6.3K

Complement control for COVID-19.

Markus Bosmann1,2,3,4

  • 1Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, 02118, MA, USA. mbosmann@bu.edu.

Science Immunology
|May 26, 2021
PubMed
Summary
This summary is machine-generated.

Excessive complement activation is linked to lung disease and poor outcomes in COVID-19 patients. Understanding this pathway is crucial for developing new treatments.

More Related Videos

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.5K
Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
08:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

3.1K

Related Experiment Videos

Last Updated: Nov 4, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
05:23

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

Published on: December 23, 2020

6.3K
Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
06:03

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

1.5K
Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19
08:48

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

3.1K

Area of Science:

  • Immunology
  • Pulmonology
  • Virology

Background:

  • The complement system is a key part of innate immunity.
  • Dysregulated complement activation has been implicated in various inflammatory conditions.
  • COVID-19 pathogenesis involves complex immune responses.

Purpose of the Study:

  • To investigate the role of complement activation in COVID-19.
  • To explore the association between complement pathways and lung injury.
  • To identify potential therapeutic targets within the complement cascade.

Main Methods:

  • Analysis of patient samples for complement activation markers.
  • In vitro studies modeling complement-mediated damage.
  • Review of existing literature on complement and viral infections.

Main Results:

  • Significant evidence of excessive complement activation in COVID-19 patients.
  • Correlation between complement activity and severity of lung disease.
  • Identification of specific complement components involved in COVID-19 pathology.

Conclusions:

  • Excessive complement activation is a significant contributor to COVID-19-associated lung disease.
  • Targeting the complement system may offer a novel therapeutic strategy for COVID-19.
  • Further research is warranted to elucidate the precise mechanisms.