Related Experiment Video

Updated: Nov 4, 2025

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

16.2K

Active Extraction of Experience of Adverse Drug Reactions in Children

Aoi Noda, Taku Obara, Michihiro Satoh

    The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
    |May 26, 2021
    PubMed

    Insights

    Japanese children experienced adverse drug reactions (ADRs), with antibacterials causing the most frequent issues like rashes. Guardians need education on reporting these medication side effects through the Direct Patient Reporting System.

    Area of Science:

    • Pediatric Pharmacology
    • Pharmacovigilance
    • Public Health

    Background:

    • Limited safety data exists for medications, over-the-counter drugs, and supplements used by Japanese children.
    • Understanding adverse drug reaction (ADR) experiences in pediatric populations is crucial for ensuring medication safety.

    Purpose of the Study:

    • To investigate and clarify the incidence of ADRs in Japanese children.
    • To evaluate efficient methods for collecting ADR data in this demographic.

    Main Methods:

    • A questionnaire survey was administered to guardians of 20,412 preschool and kindergarten children in Warabi and Toda cities, Saitama Prefecture.
    • Data collected included guardian-reported ADR experiences, suspected drugs, and specific reactions.

    Main Results:

    • Responses were obtained from 15,076 children (49.5% girls, average age 8.2 years).
    • 1.3% of guardians (196) reported ADRs, with 243 suspected drugs and 284 ADRs documented.
    • The most common medication-reaction pair involved systemic antibacterials causing rashes.

    Conclusions:

    • The study identified a significant number of potential ADRs in children, consistent with known side effects from clinical trials.
    • Findings provide valuable data on ADR frequency in the general pediatric population.
    • Enhanced education for guardians on reporting ADRs via the Direct Patient Reporting System is recommended.
    Abstract

    Keywords:
    adverse drug reactionschildrenmedicationmedication safetypediatricssupplementssurvey

    More Related Videos

    Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization09:57

    Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

    Published on: September 20, 2024

    3.0K
    Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells05:45

    Developmental Toxicity Assay Based on Real-Time Monitoring of Fibroblast Growth Factor Signal Disruption in Human Induced Pluripotent Stem Cells

    Published on: October 10, 2025

    120

    Related Concept Videos

    Pharmacovigilance01:19

    Pharmacovigilance

    Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
    This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
    In some cases, there...
    1.3K
    Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

    Pharmacokinetics in Pediatric Patients: Drug Excretion

    In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
    58
    Drug Regulation01:25

    Drug Regulation

    Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
    2.2K
    Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

    Pharmacokinetics in Pediatric Patients: Drug Metabolism

    In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
    49
    Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

    Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

    Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
    49
    Factors Affecting Drug Response: Overview01:21

    Factors Affecting Drug Response: Overview

    When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
    2.6K