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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

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Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Reticular Dermis01:15

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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Multipotency and Niche of Bulge Stem Cell01:06

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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Murine Dermal Fibroblast Isolation by FACS
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Atrophic Dermatofibroma: A Unique Dermatofibroma Variant.

Nikolas Gutierrez1, Antoanella Calame2,3, Christof Erickson4

  • 1General Practice, 1st Marine Division, 1st Combat Engineer Battalion, Camp Pendleton, USA.

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Summary

Atrophic dermatofibromas are rare skin tumors. This study details their unique clinical and pathological features, including a tendency to occur on the upper back and arms.

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acanthosisatrophicatrophydermatofibromaelasticfibersfibroblasthyperpigmentation

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Area of Science:

  • Dermatology
  • Oncology

Background:

  • Dermatofibromas are common benign skin neoplasms.
  • Atrophic dermatofibroma is a rare variant with distinct clinical and pathological characteristics.

Observation:

  • Atrophic dermatofibromas often present as flat or depressed macules, varying in color from brown to white to red.
  • Unlike classic dermatofibromas, they commonly appear on the upper back and arms.
  • Diagnosis can be clinical, but biopsy may be necessary due to varied presentations.

Findings:

  • Histopathology reveals epidermal acanthosis, basilar hyperpigmentation, fibroblast hyperplasia, and diminished elastic fibers.
  • The pathogenesis is not fully understood, but loss of elastic fibers is implicated in the atrophic appearance.
  • Two cases of biopsy-confirmed atrophic dermatofibromas in men are presented, highlighting clinical and pathological features.

Implications:

  • Increased awareness of this rare variant aids in accurate clinical diagnosis.
  • Understanding the role of elastic fiber loss may offer insights into pathogenesis.
  • Further research is needed to fully elucidate the development of atrophic dermatofibromas.