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Frailty and Kidney Transplantation: A Systematic Review and Meta-analysis
Evelien E Quint1, Donika Zogaj1, Louise B D Banning1
1Division of Transplantation Surgery, Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Transplantation Direct
|May 26, 2021
Summary
Approximately 17% of kidney transplant candidates are frail, impacting transplant outcomes. Frailty is linked to older age, fewer preemptive transplants, and worse post-transplant results, necessitating further research.
Area of Science:
- Nephrology
- Gerontology
- Transplantation Medicine
Background:
- Frailty is a decline in reserves affecting physical, cognitive, and immune functions.
- Understanding frailty's prevalence and impact is crucial for kidney transplant candidates.
Purpose of the Study:
- To systematically review evidence on frailty in kidney transplant candidates.
- To determine frailty prevalence and its association with patient characteristics and transplant outcomes.
Main Methods:
- Systematic literature search on frailty and kidney transplantation.
- Meta-analysis of 14 studies examining patient characteristics and outcomes.
- Inclusion criteria required a minimum of 2 studies for meta-analysis.
Main Results:
- Pooled frailty prevalence in kidney transplant candidates was 17.1%.
- Frailty correlated with older age, lower preemptive transplantation rates, and delayed graft function.
- Frailty was also associated with longer hospital stays post-transplantation.
Conclusions:
- Frailty affects 1 in 6 kidney transplant recipients prior to surgery.
- Frailty is linked to poorer transplant outcomes, including delayed graft function and extended hospital stays.
- Further research should investigate frailty interventions and broader adverse outcome associations.
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