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Updated: Nov 4, 2025

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Long-COVID Headache.

Paolo Martelletti1,2,3, E Bentivegna3,4, V Spuntarelli3,5

  • 1Department of Clinical and Molecular Medicine, Sapienza University, Rome, Italy.

SN Comprehensive Clinical Medicine
|May 26, 2021
PubMed
Summary

Long COVID-19, a post-viral syndrome, causes persistent headaches and other debilitating symptoms for months. This chronic headache sequela significantly impacts patients' quality of life, necessitating further research and classification.

Keywords:
ClassificationLong-Covid-19Neurological sequalaePainPeristent headache

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Public Health

Background:

  • Long COVID-19 encompasses persistent symptoms like fatigue, breathlessness, cognitive dysfunction, and psychiatric disorders following SARS-CoV-2 infection.
  • A significant portion of COVID-19 survivors, regardless of initial severity, experience a marked decline in quality of life.
  • Neurological complications are common in Long COVID-19, with persistent headaches being a frequently reported and concerning symptom.

Purpose of the Study:

  • To highlight persistent headache as a significant neurological sequela of COVID-19.
  • To address the lack of a formal definition for this specific headache type within the International Headache Society classification.
  • To emphasize the need for focused research and data collection on Long COVID-19 associated headaches.

Main Methods:

  • This study is primarily a review and discussion of existing clinical observations and literature regarding Long COVID-19 symptoms.
  • It identifies persistent headache as a key neurological disorder requiring further investigation.
  • It notes the ongoing efforts and planned clinical studies aimed at collecting data for the International Headache Society.

Main Results:

  • Persistent headache is identified as a common and potentially chronic neurological consequence of COVID-19 infection.
  • The absence of a defined classification for this headache type in the International Headache Society criteria poses a diagnostic challenge.
  • Clinical studies are being initiated to gather comprehensive data on Long COVID-19 headaches.

Conclusions:

  • Persistent headache represents a critical neurological sequela of COVID-19 that warrants significant clinical attention.
  • Standardization and classification of Long COVID-19 headache are essential for accurate diagnosis and management.
  • Further research, including large-scale data collection, is crucial for understanding and addressing this post-viral complication.