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The Utility of Circulating and Imaging Biomarkers Alone and in Combination in Heart Failure

Biyanka Jaltotage1, Girish Dwivedi1, Daryl Eng Lee Ooi2

  • 1Department of Cardiology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.

Current Cardiology Reviews
|May 26, 2021
PubMed

Insights

Biomarkers can shorten heart failure clinical trials. Using circulating and imaging biomarkers may reduce patient numbers and funding needs for heart failure research.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Trials

Background:

  • Heart failure clinical trials traditionally use hard clinical endpoints.
  • This approach leads to lengthy trials, large patient cohorts, and high costs.
  • There is a need for more efficient trial designs.

Purpose of the Study:

  • To explore the potential of circulating and imaging biomarkers as surrogates for hard clinical endpoints in heart failure trials.
  • To theorize on combining biomarkers for improved surrogate efficacy.

Main Methods:

  • Review of currently available circulating and imaging biomarkers for heart failure.
  • Theoretical framework for combining biomarkers as surrogates for clinical outcomes.

Main Results:

  • Circulating and imaging biomarkers show potential as surrogates for hard clinical endpoints.
  • Combining biomarkers may offer a more robust surrogate measure.

Conclusions:

  • Biomarker surrogates can significantly shorten clinical trials for heart failure treatments.
  • This approach can reduce the required patient cohort size and funding.
  • Biomarker-guided trials offer a more efficient pathway for heart failure research.

Keywords:
CMRCirculating and imaging biomarkersECG.cardiac mortalityheart failuremyocardial injury

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