A simple and feasible atom-precise biotinylated Cu(i) complex for tumor-targeted chemodynamic therapy

Area of Science:

• Biomedical Engineering
• Materials Science
• Oncology

Background:

• The tumor microenvironment often overexpresses hydrogen peroxide (H2O2).
• Chemodynamic therapy (CDT) offers a promising approach for cancer treatment.
• Targeted delivery of therapeutic agents is crucial for effective cancer therapy.

Purpose of the Study:

• To synthesize and characterize a novel atom-precise biotinylated Cu(i) complex.
• To investigate the catalytic activity of the complex in generating hydroxyl radicals (•OH) via Fenton-like reactions.
• To evaluate the efficacy of the complex as a tumor-targeted agent for chemodynamic therapy.

Main Methods:

• Synthesis of an atom-precise biotinylated Cu(i) complex.
• Characterization of the complex's structure and properties.
• In vitro assessment of the complex's catalytic activity in producing •OH in the presence of H2O2.
• Evaluation of tumor-targeting ability and therapeutic efficacy in relevant models.

Main Results:

• A simple and feasible atom-precise biotinylated Cu(i) complex was successfully prepared.
• The complex effectively catalyzed H2O2 to produce •OH through a Fenton-like reaction.
• The biotinylated complex demonstrated tumor-targeting capabilities.
• The agent showed effectiveness in tumor-targeted chemodynamic therapy.

Conclusions:

• The developed biotinylated Cu(i) complex is a potent agent for tumor-targeted chemodynamic therapy.
• The complex's ability to generate •OH from tumor-specific H2O2 highlights its therapeutic potential.
• This approach offers a novel strategy for enhancing cancer treatment efficacy.