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Related Experiment Videos

Bowen's disease and internal malignancy. A matched case-control study.

T Y Chuang1, G T Reizner

  • 1Section of Dermatology, University of Wisconsin, Hospital and Clinics, Madison 53792.

Journal of the American Academy of Dermatology
|July 1, 1988
PubMed
Summary
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Bowen's disease, a skin condition, was studied for its link to internal cancers. Research found no significant evidence that Bowen's disease indicates a higher risk of internal malignancy in elderly white men.

Area of Science:

  • Dermatology
  • Oncology
  • Epidemiology

Background:

  • Bowen's disease (squamous cell carcinoma in situ) has been historically considered a potential indicator of internal malignancy.
  • Previous reports suggested a correlation, necessitating further investigation into this association.

Purpose of the Study:

  • To investigate the association between Bowen's disease and the presence of internal malignancies.
  • To determine if Bowen's disease serves as a significant skin marker for occult internal cancers in elderly white men.

Main Methods:

  • A matched case-control study was designed.
  • Fifty male patients diagnosed with Bowen's disease were matched with 100 control patients (50 with basal cell carcinoma, 50 with other dermatoses) based on age, sex, race, and biopsy date.

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Main Results:

  • Of the 50 patients with Bowen's disease, 12 (24%) had internal malignancies.
  • Internal malignancies were found in 18% of the basal cell carcinoma group and 14% of the other dermatoses group.
  • The observed frequencies of internal malignancies were not statistically different between the Bowen's disease cohort and the control groups.

Conclusions:

  • The study did not find statistically significant evidence to support Bowen's disease as a skin marker for internal malignancy in the elderly white male population.
  • The findings suggest that the association between Bowen's disease and internal malignancy may be less pronounced than previously thought in this demographic.