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Related Experiment Video

Updated: Nov 4, 2025

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Comparative Analysis of Single and Combined Antipyretics Using Patient-Generated Health Data: Retrospective

Yu Rang Park1, Hyery Kim2, Ji Ae Park1

  • 1Department of Biomedical Systems Informatics, Yonsei University College of Medicine, Seoul, Republic of Korea.

JMIR Mhealth and Uhealth
|May 26, 2021
PubMed
Summary

Single antipyretics are effective for reducing fever in children. Combination antipyretic therapy did not demonstrate significant advantages over single-drug use for fever reduction.

Keywords:
appscombination antipyreticscomparative analysisfeverfever managementmHealthpatient-generated health data

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Area of Science:

  • Pediatric medicine
  • Pharmacology
  • Health informatics

Background:

  • Fever is a common childhood symptom and a natural immune response.
  • Limited studies exist on the effectiveness of single versus combined antipyretic treatments.
  • Large-scale patient-generated health data offers a novel approach to study antipyretic efficacy.

Purpose of the Study:

  • To analyze antipyretic combination patterns in children.
  • To compare the effectiveness of single and combination antipyretic therapies.
  • To utilize mobile health app data for clinical insights.

Main Methods:

  • Analysis of 3,584,748 temperature and 1,076,002 antipyretic records from 104,337 children (July 2015-June 2017).
  • Comparison of antipyretic efficacy using the area under the temperature change curve (AUC) over 6, 8, 10, and 12 hours.
  • Stratification of data by single versus combination antipyretic use and body temperature.

Main Results:

  • Acetaminophen was the most frequent single antipyretic; acetaminophen plus dexibuprofen was the most common combination.
  • Combination antipyretic use increased with higher temperatures.
  • Single antipyretics showed significantly greater fever reduction (higher AUC) compared to combination therapies, particularly within the first 6 hours.

Conclusions:

  • Combination antipyretics did not offer a clear benefit over single agents for fever reduction in children.
  • Single antipyretic therapy, primarily acetaminophen, is effective for managing fever.
  • Further research into optimal antipyretic strategies is warranted.