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Updated: Nov 4, 2025
Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research
Published on: September 8, 2023
Immune evasion of SARS-CoV-2 variants of concern is driven by low affinity to neutralizing antibodies
Matheus V F Ferraz1, Emerson G Moreira, Danilo F Coêlho
1Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, PE, Brazil. roberto.lins@cpqam.fiocruz.br.
Abstract:
SARS-CoV-2 VOC immune evasion is mainly due to lower cross-reactivity from previously elicited class I/II neutralizing antibodies, while increased affinity to hACE2 plays a minor role. The affinity between antibodies and VOCs is impacted by remodeling of the electrostatic surface potential of the Spike RBDs. The P.3 variant is a putative VOC.
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