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Corneal Tomographic Analysis Among Patients With Thyroid Gland Dysfunction.

Rania M Bassiouny, Eman A Awad, Walid Gaafar

Journal of Refractive Surgery (Thorofare, N.J. : 1995)

|May 26, 2021

Summary

This summary is machine-generated.

Thyroid dysfunction significantly alters corneal tomography. Hyperthyroidism is linked to thinner corneas and keratoconus-like changes, while hypothyroidism shows increased corneal thickness.

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Area of Science:

Ophthalmology
Endocrinology
Medical Imaging

Background:

Thyroid gland dysfunction can affect various systemic functions.
Corneal changes in thyroid dysfunction are not fully understood.
Ocular manifestations of thyroid disease are common.

Purpose of the Study:

To analyze corneal tomographic parameters in patients with thyroid dysfunction.
To compare corneal tomography between thyroid dysfunction patients and healthy controls.
To investigate the correlation between corneal parameters and thyroid hormone levels.

Main Methods:

Case-control study involving 50 patients with thyroid dysfunction and 50 controls.
Corneal tomography performed using Pentacam.
Comparison of Pentacam parameters and correlation with serum TSH and free T4 levels.

Main Results:

Hypothyroidism associated with increased corneal thickness (CCT, CTmin).
Hyperthyroidism linked to thinner corneas (ARTmax) and abnormal tomographic indices (PPI, posterior elevation).
Corneal thickness correlated with TSH and free T4 levels; non-autoimmune thyroid dysfunction showed thinner corneas.

Conclusions:

Thyroid dysfunction is associated with significant corneal tomographic changes.
Hyperthyroidism may increase the risk of keratoconus.
Regular screening for keratoconus is recommended in thyroid dysfunction patients.