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An Operant Intra-/Extra-dimensional Set-shift Task for Mice

An Operant Intra-/Extra-dimensional Set-shift Task for Mice

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Task-dependent mixed selectivity in the subiculum.

Debora Ledergerber¹, Claudia Battistin¹, Jan Sigurd Blackstad¹

¹Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrre s gate 9, MTFS, 7489 Trondheim, Norway.

|May 26, 2021

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The subiculum (SUB) and CA1 regions of the hippocampus encode spatial navigation information. The subiculum shows stronger mixed selectivity for position, head direction, and speed, enabling more precise decoding of navigational variables.

Area of Science:

Neuroscience
Cognitive Neuroscience
Computational Neuroscience

Background:

The hippocampus, particularly CA1 and subiculum (SUB), is crucial for spatial navigation and memory.
Understanding how these regions encode complex navigational information like position, head direction, and speed is vital for comprehending brain function.
Previous research suggests distinct but overlapping roles for CA1 and SUB in spatial representation.

Purpose of the Study:

To investigate and compare the encoding of position, head direction, and speed in simultaneously recorded CA1 and SUB neurons.
To determine the degree of mixed selectivity for these navigational variables in both hippocampal subfields.
To assess the impact of navigational context (goal-directed vs. free foraging) on neural representations.

Main Methods:

Keywords:

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Last Updated: Nov 4, 2025

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Simultaneous electrophysiological recordings from CA1 and SUB neurons in freely moving animals.
Analysis of neuronal tuning properties to position, head direction, and running speed.
Decoding analyses to quantify the precision of navigational variable representation.

Main Results:

Neurons in both CA1 and SUB exhibit conjunctive responses to position, head direction, and speed.
The subiculum demonstrates a greater degree of mixed selectivity compared to CA1, especially during goal-directed navigation.
Navigational variables were decoded with higher precision from SUB neurons than CA1 neurons, using a similar number of cells.

Conclusions:

The subiculum's enhanced mixed-selective coding contributes to efficient transmission of hippocampal spatial information to downstream brain areas.
This mixed representation in SUB may facilitate flexible and robust navigation.
Findings highlight the distinct computational roles of hippocampal subfields in spatial cognition.