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Related Experiment Video

Updated: Nov 4, 2025

Reliable Isolation of Central Nervous System Microvessels Across Five Vertebrate Groups

Reliable Isolation of Central Nervous System Microvessels Across Five Vertebrate Groups

Published on: January 12, 2020

Validating layer-specific VASO across species.

Laurentius Renzo Huber¹, Benedikt A Poser¹, Amanda L Kaas¹

¹MBIC, Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands.

|May 26, 2021

Summary

This summary is machine-generated.

This study validates vascular-space-occupancy (VASO) fMRI for precise, layer-specific brain activity mapping. Findings confirm VASO reliably measures cerebral blood volume changes, enhancing neuroscience research.

Keywords:

Cerebral blood volume Concurrent imaging Depth-dependent fMRI Draining vein Laminar Layer MION Optical imaging spectroscopy Pre-clinical Somatosensory stimulation Sub-millimetre VASO.fMRI

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Area of Science:

Neuroimaging
Physiology
Neuroscience

Background:

Cerebral blood volume (CBV) is crucial for functional MRI (fMRI) to map neural activity.
Ultra-high-field MRI enables non-invasive CBV-weighted fMRI signals across cortical layers.
Vascular-space-occupancy (VASO) fMRI is widely used but its layer-dependent contrast mechanisms require validation in humans.

Purpose of the Study:

To validate the signal source of layer-dependent SS-SI VASO fMRI.
To compare VASO-derived CBV measures with concurrent total hemoglobin changes using intrinsic optical imaging spectroscopy (OIS).
To enable cross-species comparison of layer-specific CBV changes using VASO.

Main Methods:

Multi-modal imaging in a rat model under neuronal activation and respiratory challenge.
Direct comparison of VASO-derived CBV with OIS measures of total hemoglobin.
Comparison of quantified cortical layer profiling between VASO and contrast-enhanced fMRI using MION.

Main Results:

Cortical layer profiling showed agreement between VASO and MION-enhanced fMRI.
VASO responses demonstrated high spatial localization to cortical layers, avoiding confounding large draining veins.
VASO-based CBV reactivity was higher in humans (3.1 ± 1.2 fold increase) compared to rats.

Conclusions:

The study confirms VASO contrast reliably estimates layer-specific CBV changes.
This validation enhances the neuronal interpretability of human layer-dependent VASO fMRI.
VASO fMRI is a valuable tool for neuroscience studies, overcoming limitations of BOLD fMRI in mapping neural activity.