Related Experiment Video
Updated: Nov 4, 2025
Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Toluene-induced leukodystrophy from glue sniffing
Yue Hui Lau1, Ahmad Shahir Mawardi2, Norzaini Rose Zain3
1Neurology Department, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia andrealau38@gmail.com.
Abstract:
A 33-year-old man with a history of chronic toluene abuse through glue sniffing, developed tremors, cerebellar signs and cognitive decline. MR scan of the brain showed global cerebral and cerebellar atrophy with symmetrical T2-weighted hypointensities in the basal ganglia, thalami and midbrain. After stopping glue sniffing, his tremors, ataxia of gait, speech and cognition partially improved. Early recognition and intervention of toluene-induced leukodystrophy could prevent ongoing morbidity and premature mortality.
