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Published on: May 24, 2024
Conversion therapy and maintenance therapy for primary hepatocellular carcinoma
Hongyuan Zhou1, Tianqiang Song1
1Department of Hepatobiliary, HCC Research Center for Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Conversion therapy aims to make advanced liver cancer operable, offering a chance for cure. Treatment plans are personalized after initial therapy to maximize patient survival benefits.
Area of Science:
- Hepatobiliary Oncology
- Surgical Oncology
- Medical Oncology
Background:
- Hepatocellular carcinoma (HCC) is a primary liver cancer.
- Surgery offers the only chance for cure in HCC patients.
- Most Chinese HCC patients present with advanced disease, ineligible for surgery.
Purpose of the Study:
- To explore conversion therapy for unresectable or potentially resectable HCC.
- To identify effective conversion therapy modalities and maintenance strategies.
- To improve long-term survival outcomes for advanced HCC patients.
Main Methods:
- Review of local treatments: transarterial chemoembolization (TACE), transarterial radioembolization (TARE), hepatic arterial infusion chemotherapy (HAIC).
- Review of systemic treatments: targeted therapy alone or with immunotherapy.
- Review of combination therapies: TACE/TARE/HAIC with radiation, targeted therapy, or immunotherapy.
Main Results:
- Conversion therapy aims to render advanced HCC resectable.
- Various local, systemic, and combined treatment modalities are employed.
- Maintenance treatment is tailored post-conversion to optimize survival.
Conclusions:
- Conversion therapy is a critical strategy for advanced HCC in China.
- Personalized treatment plans combining modalities are essential.
- Optimizing maintenance therapy post-conversion is key for survival benefits.
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