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Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines
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Enhancer release and retargeting activates disease-susceptibility genes

Soohwan Oh1, Jiaofang Shao2, Joydeep Mitra3

  • 1Howard Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.

Nature
|May 27, 2021
PubMed
Summary

When a preferred gene promoter is lost, enhancers can switch targets, activating new promoters. This "enhancer release and retargeting" mechanism, influenced by CTCF binding, can activate disease-susceptibility genes.

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