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Updated: Nov 4, 2025

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
Published on: March 21, 2025
Discrepancy between Multiparametric Magnetic Resonance Imaging and 68Ga Prostate-Specific Membrane Antigen Positron
Naveen Jose Moolan1, Vijay Harish Somasundaram1, Bindu Mangalath Rajamma2
1Department of Nuclear Medicine and Molecular Imaging, Amrita Institute of Medical Sciences, Kochi, Kerala, India.
Abstract:
Conventionally, multiparametric magnetic resonance imaging (mpMRI) incorporating T2-weighted, diffusion-weighted, and dynamic contrast-enhanced sequences is considered the standard for detection and staging of clinically important prostate cancer (PCa).[1] The 68gallium (68Ga)-labeled positron emission tomography (PET) tracer targeting prostate-specific membrane antigen (PSMA), 68Ga-PSMA PET, is a promising tool for detection, localization, and staging carcinoma prostate.[2] Here, we present a case of PCa, showing incongruence between 68Ga-PSMA PET and the corresponding mpMRI findings. Moreover, the final histopathology revealed a surprise, which exemplifies the complementary nature of combining 68Ga-PSMA PET and mpMRI in the diagnosis and staging of carcinoma prostate.
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