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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Updated: Nov 4, 2025

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Risk Factors for Endophthalmitis Following Open Globe Injuries: A 17-Year Analysis.

Asad F Durrani1, Peter Y Zhao1, Yunshu Zhou1

  • 1Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, MI, USA.

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Summary
This summary is machine-generated.

Prompt globe repair and subconjunctival antibiotics significantly reduce endophthalmitis risk after open globe injury (OGI). This study highlights key factors influencing infection rates in trauma patients.

Keywords:
endophthalmitisintraocular foreign bodyocular traumaopen globe injury

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Area of Science:

  • Ophthalmology
  • Trauma Surgery
  • Infectious Disease

Background:

  • Open globe injury (OGI) poses a significant risk for endophthalmitis.
  • Understanding endophthalmitis rates and risk factors is crucial for effective management.

Purpose of the Study:

  • To determine the incidence of endophthalmitis following OGI.
  • To identify risk factors associated with endophthalmitis development post-OGI.

Main Methods:

  • Retrospective chart review of OGI patients at the University of Michigan (2000-2017).
  • Inclusion criteria: OGI, 30-day pre-injury exclusion, and ≥30 days follow-up.
  • Main outcome: Rate of endophthalmitis; multivariate analysis for risk factors.

Main Results:

  • Endophthalmitis occurred in 4.3% (25/586) of eyes with OGI.
  • Risk factors for endophthalmitis: delayed globe repair, zone I injury, and need for additional surgery.
  • Subconjunctival antibiotic injection at globe closure reduced endophthalmitis risk (OR 0.3).

Conclusions:

  • Prompt globe closure and subconjunctival antibiotics may lower endophthalmitis risk in OGI.
  • Standard prophylactic antibiotic regimens (systemic/intravitreal) did not increase endophthalmitis rates.