Monitoring and Improving Naltrexone Adherence in Patients with Substance Use Disorder
Virginia Perez-Macia1,2, Mireia Martinez-Cortes3, Jesus Mesones1,2
1Vinalopó University Hospital, Elche, Spain.
Patient Preference and Adherence
|May 27, 2021
Summary
Naltrexone adherence in substance use disorders shows no superiority over other treatments. Reinforcement systems may improve adherence, but further research into psychosocial factors and patient preferences is needed.
Area of Science:
- Pharmacology
- Addiction Medicine
- Systematic Review
Background:
- Naltrexone is an opioid antagonist for opioid and alcohol use disorders.
- Treatment adherence is a significant challenge in these populations, impacting therapeutic efficacy.
- Understanding factors influencing naltrexone adherence is crucial for improving patient outcomes.
Purpose of the Study:
- To comprehensively summarize existing evidence on naltrexone adherence in substance use disorders.
- To identify potential variables that influence adherence to naltrexone treatment.
Main Methods:
- Systematic review of studies published between January 1, 2011, and September 2020.
- Searches conducted in PubMed and Embase databases.
- Inclusion of 36 studies evaluating naltrexone in adults with alcohol or opioid use disorder.
Main Results:
- Naltrexone did not demonstrate superior adherence or abstinence rates compared to alternative treatments.
- Reinforcement systems emerged as a potentially beneficial strategy to enhance naltrexone adherence.
- No significant differences in adherence were observed between naltrexone and other available treatments.
Conclusions:
- Further investigation into psychosocial variables is necessary to improve naltrexone adherence.
- Incorporating patient preferences into treatment strategies may enhance the generalizability of study findings.
- Adherence remains a critical factor in the effective management of substance use disorders with naltrexone.
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