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Association Between Interleukin-12 and Sarcopenia.

Yuan-Yuei Chen^1,2,3, Tung-Wei Kao³, Yi-Lin Chiu⁴

¹Department of Pathology, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Journal of Inflammation Research

|May 27, 2021

Summary

This summary is machine-generated.

Interleukin-12 (IL-12) may indicate early sarcopenia in older adults. Lower IL-12 levels correlate with muscle weakness and slower gait, suggesting its potential as a diagnostic marker for age-related muscle loss.

Keywords:

IL-12 TGF-β gender macrophage sarcopenia

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Area of Science:

Gerontology
Immunology
Muscle Physiology

Background:

Cytokines secreted by macrophages are implicated in skeletal muscle aging.
Research is exploring the link between these cytokines and sarcopenia progression in the elderly.

Purpose of the Study:

To investigate the impact of specific cytokines on sarcopenia development in an elderly population.
To determine if cytokines can serve as early diagnostic indicators for sarcopenia.

Main Methods:

Retrospective analysis of 120 elderly adults (≥65 years) from 2015-2019.
Sarcopenia assessment based on European Working Group criteria (2019).
Utilized Gene Expression Omnibus (GEO) data for macrophages and cytokines, assessing muscle strength, mass, gait speed, TGF-β, and IL-12.

Main Results:

Low muscle strength and gait speed were negatively associated with Interleukin-12 (IL-12).
Higher sarcopenia severity correlated with lower IL-12 and increased Tumor Growth Factor-beta (TGF-β).
Decreased IL-12 and increased TGF-β were linked to diagnosed sarcopenia; higher IL-12 reduced sarcopenia occurrence (OR 0.36).

Conclusions:

Interleukin-12 (IL-12) shows potential as an early diagnostic biomarker for sarcopenia in the elderly.
Cytokine profiles, particularly IL-12 and TGF-β, are associated with age-related muscle decline.