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Updated: Nov 4, 2025

A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
COVID-19-Induced Hypoxia With Accompanying Syncope Event and Traumatic Injury
Christ Ordookhanian1, Ryan F Amidon2, Sean W Kaloostian3
1Medicine, University of California Riverside School of Medicine, Riverside, USA.
Insights
A novel coronavirus infection caused multi-organ hypoxia in a healthy 35-year-old male. This led to a syncopal episode, resulting in a minor subarachnoid hemorrhage from head trauma.
Area of Science:
- Medicine
- Infectious Diseases
- Neurology
Background:
- Coronaviruses have caused respiratory pathology since the 1960s.
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19.
- COVID-19 presents with severe respiratory pathology and systemic complications.
Observation:
- The first US COVID-19 case was identified January 21, 2020.
- A healthy 35-year-old male contracted SARS-CoV-2.
- The infection led to multi-organ hypoxia and a syncopal episode.
Findings:
- The syncopal episode resulted in physical trauma.
- A minor subarachnoid hemorrhage was diagnosed.
- This case highlights potential neurological complications of COVID-19.
Implications:
- COVID-19 can cause severe systemic and neurological consequences.
- Understanding these complications is crucial for patient management.
- Further research is needed on SARS-CoV-2's impact on various organ systems.
Abstract:
The Centers for Disease Control and Prevention identified the first case of the novel coronavirus disease 2019 (COVID-19) on January 21, 2020 in the United States. Since its arrival, the virus has caused widespread havoc on the nation as a whole as well as on all individuals. The coronavirus family is not new to the field of medicine. In fact, the viral pathogenicity dates back to the early 1960s, with more information on the respiratory preference and the ability to cause acute respiratory pathology coming later in 2002. The novel coronavirus, severe acute respiratory syndrome coronavirus 2, causes a disease commonly referred to as COVID-19, which has a well documented course of severe respiratory pathology along with interesting systemic consequences that often complicate the clinical picture. This case presents an otherwise healthy young 35-year-old male who contracted the novel coronavirus, leading to multi-organ hypoxia and triggering a syncopal episode which resulted in physical trauma to the head leading to a minor subarachnoid hemorrhage.
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