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Pathological nerve patterns in human basal cell carcinoma.

Giovanni Nicoletti¹, Marco Mario Tresoldi², Anna Maria Gatti³

¹Plastic and Reconstructive Surgery, Department of Clinical Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Viale Brambilla, 74, 27100 Pavia, Italy, Advanced Technologies for Regenerative Medicine and Inductive Surgery Research Center, University of Pavia, Viale Brambilla, 74, 27100 Pavia, Italy.

European Journal of Dermatology : EJD

|May 27, 2021

Summary

Nerve fibers are a significant factor in basal cell carcinoma (BCC) development. This study identified three distinct patterns of nerve fiber distribution within BCC tumors, suggesting nerves are a crucial component alongside epithelium and stroma.

Keywords:

basal cell carcinoma embryogenesis nerve skin adnexa skin cancer skin innervation

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Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

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Published on: April 29, 2013

Area of Science:

Oncology
Dermatology
Neuroscience

Background:

Basal cell carcinoma (BCC) is characterized by the interaction between epithelium and stroma.
Nerve fibers are increasingly recognized for their active roles in various cancers.

Purpose of the Study:

To investigate the distribution and patterns of nerve fibers within basal cell carcinoma (BCC) tissue.
To explore the potential role of nerves as a third component in BCC tissue involvement.

Main Methods:

A prospective observational study was conducted on 10 BCC surgical excision specimens.
Punch biopsies were analyzed using indirect immunofluorescence targeting protein gene product 9.5 to stain nerve fibers.
Histological sub-types of BCC were identified and correlated with nerve fiber patterns.

Main Results:

Three distinct patterns of nerve fiber distribution within BCCs were identified.
Pattern 1: Normal skin nerve pattern with dislodged fibers.
Pattern 2: Tangled nerve fibers resembling piloneural collars.
Pattern 3: Sub-epidermal nerve crowding and epidermal hyperinnervation, similar to mechanosensory organs.

Conclusions:

Nerve fibers exhibit specific distribution patterns within basal cell carcinoma.
The involvement of BCC tissue may be better understood as a triad of epithelium, stroma, and nerves.
This suggests a significant, potentially active, role for nerves in basal cell carcinoma development and progression.