Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Highly sensitive wireless dual-spiral resonant contact lens for continuous intraocular pressure monitoring.

Lab on a chip·2026
Same author

Self-organized criticality in aquatic robot swarm.

Science advances·2026
Same author

Automated DWI-FLAIR mismatch assessment in stroke using DWI only.

European stroke journal·2026
Same author

Does the susceptibility vessel sign influence the effectiveness of intravenous thrombolysis before endovascular thrombectomy in acute ischaemic stroke?

European stroke journal·2026
Same author

Hemorrhagic transformation after endovascular treatment: Baseline infarct volume is a better predictor than infarct growth rate.

European stroke journal·2026
Same author

Automated DWI-FLAIR mismatch assessment in stroke using DWI only.

European stroke journal·2025

Related Experiment Video

Updated: Nov 4, 2025

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

17.5K

Stretch-driven microfluidic chip for nucleic acid detection.

Xiang Li1, Xiaoyu Zhao1, Weihao Yang1

  • 1Bio-manufacturing Engineering Laboratory, Tsinghua Shenzhen International Graduate School, Tsinghua University, Guangdong, Shenzhen, China.

Biotechnology and Bioengineering
|May 27, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces a novel microfluidic chip for rapid molecular diagnosis. The portable device uses stretching for nucleic acid detection, showing promise for infectious disease testing in resource-limited settings.

Keywords:
hand-poweredmicrofluidicsnucleic acid detectionstretch-driven

More Related Videos

Microfluidic Chip Fabrication and Method to Detect Influenza
09:43

Microfluidic Chip Fabrication and Method to Detect Influenza

Published on: March 26, 2013

15.2K
Visual Detection of Multiple Nucleic Acids in a Capillary Array
08:56

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

7.4K

Related Experiment Videos

Last Updated: Nov 4, 2025

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
14:53

A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis

Published on: September 10, 2014

17.5K
Microfluidic Chip Fabrication and Method to Detect Influenza
09:43

Microfluidic Chip Fabrication and Method to Detect Influenza

Published on: March 26, 2013

15.2K
Visual Detection of Multiple Nucleic Acids in a Capillary Array
08:56

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

7.4K

Area of Science:

  • Biotechnology
  • Medical Diagnostics
  • Microfluidics

Background:

  • Molecular diagnosis is crucial for pathogen detection.
  • Portable nucleic acid detection chips offer solutions for resource-limited healthcare settings.
  • Microfluidic chip technology is an area of active research for diagnostics.

Purpose of the Study:

  • To develop a novel microfluidic chip for nucleic acid detection.
  • To utilize stretching as the primary driving force for sample manipulation.
  • To demonstrate the chip's capability for detecting coronavirus disease 2019 (COVID-19).

Main Methods:

  • A new microfluidic chip design was developed.
  • Capillary force was used for sample introduction.
  • Tensile force actuated strain valves, and a spring pump drove fluid flow.
  • Reverse transcription loop-mediated isothermal amplification (RT-LAMP) was employed for detection.

Main Results:

  • The microfluidic chip successfully performed nucleic acid detection.
  • The system enabled qualitative detection of COVID-19.
  • Visual color change in the detection chamber indicated test results.

Conclusions:

  • The developed microfluidic chip offers a promising platform for portable molecular diagnostics.
  • Stretching-driven fluid control is a viable mechanism for microfluidic sample manipulation.
  • The chip demonstrates potential for rapid and accessible infectious disease testing, including COVID-19.