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Related Experiment Videos

Meningiomas and hemorrhagic diathesis.

K Oka1, H Tsuda, K Kamikaseda

  • 1Department of Neurosurgery, Faculty of Medicine, Kyushu University, Japan.

Journal of Neurosurgery
|September 1, 1988
PubMed
Summary

Surgery for meningioma can cause bleeding issues due to fibrinolytic abnormalities. Antiplasmin agents effectively reduced blood loss in patients with hyperfibrinolysis during these operations.

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Area of Science:

  • Neurosurgery
  • Hematology
  • Surgical Oncology

Background:

  • Meningiomas are primary tumors of the brain and spinal cord.
  • Surgery is the primary treatment for meningiomas.
  • Hemostatic complications can occur during meningioma surgery.

Observation:

  • Studied 13 patients undergoing surgery for meningiomas.
  • Observed fibrinolytic abnormalities in three patients.
  • These abnormalities included increased plasma fibrinolytic activity.

Findings:

  • Patients with fibrinolytic abnormalities showed hemorrhagic diathesis in operative wounds.
  • Associated consumptive coagulopathy was noted, with increased fibrin/fibrinogen degradation products and decreased fibrinogen.
  • Antiplasmin agents, gabexate and tranexamic acid, were effective in minimizing intraoperative and postoperative blood loss.

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Implications:

  • Abnormal hyperfibrinolysis is implicated in hemostatic difficulties during meningioma surgery.
  • Antiplasmin agents represent a potential therapeutic strategy for managing bleeding complications.
  • Further research into the mechanisms of hyperfibrinolysis in meningioma patients is warranted.