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A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
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Systematic review and meta-analysis on the safety of dalbavancin

N Monteagudo-Martínez1, J Solís-García Del Pozo2, Ichiro Ikuta3

  • 1Department of Pharmacy. Gerencia De Atención Integrada De Villarrobledo, Albacete, Spain.

Expert Opinion on Drug Safety
|May 27, 2021
PubMed
Abstract

Insights

Dalbavancin, an antimicrobial, shows favorable results and a comparable safety profile to other antibiotics. This meta-analysis found it well-tolerated with a significantly lower mortality rate.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Clinical Trials

Background:

  • Dalbavancin is a semisynthetic lipoglycopeptide antimicrobial.
  • It exhibits activity against Gram-positive bacteria, including anaerobes.

Purpose of the Study:

  • To evaluate the efficacy and safety of dalbavancin compared to other antibiotics.
  • To assess treatment-emergent adverse effects and mortality rates associated with dalbavancin therapy.

Main Methods:

  • Meta-analysis of randomized controlled trials (RCTs) and large case series.
  • Searched PubMed and Cochrane databases up to December 14, 2020.
  • Included 6 RCTs with 3,073 patients meeting the criteria.

Main Results:

  • Dalbavancin treatment showed favorable results (OR 0.79; p=0.01).
  • Adverse effects were comparable (30.6% vs 38.1%), with similar discontinuation rates.
  • Dalbavancin therapy demonstrated a statistically significant lower mortality rate (OR 0.26; p=0.03).
  • No significant difference in severe adverse effects (OR 0.77; p=0.19).

Conclusions:

  • Dalbavancin possesses a comparable safety profile to other antibiotics.
  • The drug is well-tolerated by patients.
  • Dalbavancin therapy is associated with reduced mortality.
Keywords:
Dalbavancinclinical trialsafetyside effectsystematic review

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