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Harnessing the Endocannabinoid System: What It Means for the Anesthesia Provider
1was a student registered nurse anesthetist at Virginia Commonwealth University in Richmond, Virginia, at the time she wrote this article. She graduated in December, 2019. She earned her BSN from the University of Nebraska Medical Center College of Nursing in Lincoln, Nebraska, in 2009.
Abstract:
The desire to limit narcotic use, coupled with a desire for efficacious pain relief with few side effects, has led researchers and providers alike to focus on the possibilities inherent in the exploitation of the endocannabinoid system. In particular, fatty acid amide hydrolase (FAAH) inhibitors and monoamine glycerol lipase (MAGL) inhibitors hold great potential to become some of the next new classifications of pharmaceuticals formulated for not only pain relief, but a host of other conditions as well. This course is designed to introduce the reader to the endocannabinoid system, its components and mechanism of action, and examine how its effects are currently employed in anesthesia. Results from preclinical and clinical trials will be analyzed. In addition, concerns regarding long-term effects from the activation of the endocannabinoid system are discussed.
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