Common Marmoset Model of α-Synuclein Propagation
Masami Masuda-Suzukake1, Aki Shimozawa1, Masashi Hashimoto1
1Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.
Methods in Molecular Biology (Clifton, N.J.)
|May 27, 2021
Abstract:
The propagation of assembled α-synuclein (αS) is key to understanding the pathological mechanisms of synucleinopathies such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy.Here we describe a nonhuman primate model of αS propagation using common marmosets (Callithrix jacchus) with an intracerebral injection of synthetic preformed αS fibrils. This protocol enables observation of the formation of phosphorylated αS pathology and its propagation three months after the injection.
