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Updated: Nov 4, 2025

Generation of Human Chimeric Antigen Receptor Regulatory T Cells
Published on: January 3, 2025
Impact of Diverse Ion Channels on Regulatory T Cell Functions
Laura Vinnenberg1, Stefanie Bock1, Petra Hundehege1
1Department of Neurology, Institute of Translational Neurology, University Hospital Muenster, Muenster, Germany.
Abstract:
The population of regulatory T cells (Tregs) is critical for immunological self-tolerance and homeostasis. Proper ion regulation contributes to Treg lineage identity, regulation, and effector function. Identified ion channels include Ca2+ release-activated Ca2+, transient receptor potential, P2X, volume-regulated anion and K+ channels Kv1.3 and KCa3.1. Ion channel modulation represents a promising therapeutic approach for the treatment of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis. This review summarizes studies with gene-targeted mice and pharmacological modulators affecting Treg number and function. Furthermore, participation of ion channels is illustrated and the power of future research possibilities is discussed.
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