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Updated: Nov 4, 2025

Effects of Surgical Masks on Cardiopulmonary Function in Healthy Subjects
Published on: February 12, 2021
Effects of N95 Mask Use on Pulmonary Function in Children
Riccardo Lubrano1, Silvia Bloise1, Alessia Marcellino1
1Department of Maternal and Childhood and Urologic Sciences, UOC of Pediatrics and Neonatology-Polo Pontino, Sapienza Università di Roma, Rome, Italy.
Objective:
To assess whether use of an N95 mask by children is associated with episodes of desaturation or respiratory distress.
Study Design:
Twenty-two healthy children were assigned at random to 1 of 2 groups: one group wearing N95 masks without an exhalation valve and the other group wearing N95 masks with an exhalation valve. We tracked changes in partial pressure of end-tidal carbon dioxide (PETCO2), oxygen saturation, pulse rate, and respiratory rate over 72 minutes of mask use. All subjects were monitored every 15 minutes, the first 30 minutes while not wearing a mask and the next 30 minutes while wearing a mask. They then performed a 12-minute walking test.
Results:
The children did not experience a statistically significant change in oxygen saturation or pulse rate during the study. There were significant increases in respiratory rate and PETCO2 in the children wearing an N95 mask without an exhalation valve, whereas these increases were seen in the children wearing a mask with an exhalation valve only after the walking test.
Conclusions:
The use of an N95 mask could potentially cause breathing difficulties in children if the mask does not have an exhalation valve, particularly during a physical activity. We believe that wearing a surgical mask may be more appropriate for children.
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