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Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer
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Differences in bioavailability and tissue accumulation efficiency of (all-E)- and (Z)-carotenoids: A comparative
Masaki Honda1, Soo Takasu2, Kiyotaka Nakagawa2
1Faculty of Science & Technology, Meijo University, Nagoya, Aichi 468-8502, Japan.
Food Chemistry
|May 27, 2021
Summary
Carotenoid Z-isomers show superior bioavailability and tissue accumulation compared to all-E-isomers. Diets rich in Z-isomers significantly boost carotenoid levels, potentially offering greater health benefits due to higher antioxidant activity.
Area of Science:
- Nutritional Science
- Biochemistry
- Pharmacokinetics
Background:
- Carotenoids are vital plant pigments with antioxidant properties.
- Commercial carotenoids exist as all-E-isomers and Z-isomers.
- Differences in isomer bioavailability and tissue accumulation are not fully understood.
Purpose of the Study:
- To compare the bioavailability and tissue accumulation of all-E- and Z-isomer-rich carotenoids.
- To investigate the impact of isomer-rich diets on carotenoid levels in plasma and tissues.
- To assess the potential health implications of carotenoid isomer differences.
Main Methods:
- Oral administration of all-E- and Z-isomer-rich lycopene, beta-carotene, and lutein to rats.
- Quantification of carotenoid concentrations in plasma and liver tissues.
- Analysis of total Z-isomer ratios in plasma and tissues.
Main Results:
- Z-isomer-rich carotenoid diets significantly increased plasma and tissue concentrations compared to all-E-isomer diets.
- For lycopene, Z-isomer-rich diets resulted in 6.2-fold higher plasma and 11.6-fold higher liver concentrations.
- Diets rich in Z-isomers improved the total Z-isomer ratio in plasma and tissues.
Conclusions:
- Carotenoid Z-isomers exhibit higher bioavailability and tissue accumulation efficiency than all-E-isomers.
- Increased Z-isomer levels in the body may enhance antioxidant capacity.
- Carotenoid Z-isomers hold promise for improved health benefits.
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