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Polycarbonate intraocular lenses.

M Yalon1, E P Goldberg, D Osborn

  • 1Department of Materials Science, University of Florida, Gainesville 32611.

Journal of Cataract and Refractive Surgery
|July 1, 1988
PubMed
Summary
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Bisphenol-A polycarbonate shows promise as a superior material for ocular implants, including intraocular lenses (IOLs). This polymer offers enhanced strength and sterilizability, potentially improving upon existing materials for better patient outcomes.

Area of Science:

  • Ophthalmic biomaterials research
  • Polymer science and engineering

Background:

  • Polymethylmethacrylate (PMMA) is a common material for intraocular lenses (IOLs).
  • There is a need for improved polymer materials offering enhanced mechanical and optical properties for ocular implants.

Purpose of the Study:

  • To investigate Bisphenol-A polycarbonate as a potential advanced polymer for ocular implants, particularly intraocular lenses (IOLs).
  • To evaluate the properties and biocompatibility of polycarbonate for IOL applications.

Main Methods:

  • Characterization of Bisphenol-A polycarbonate properties relevant to IOLs.
  • Evaluation of sterilizability (autoclave, gamma radiation).
  • In vivo biocompatibility assessment through anterior chamber implantation in rabbits.

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Main Results:

  • Polycarbonate offers opportunities for developing tougher, stronger, one-piece IOLs.
  • Polycarbonate exhibits favorable sterilizability and a higher refractive index compared to PMMA.
  • Polycarbonate IOLs demonstrated good tolerability in rabbit anterior chambers over 2.5 years.

Conclusions:

  • Bisphenol-A polycarbonate is a promising material for next-generation intraocular lenses.
  • Polycarbonate's properties suggest advantages for various ocular implant applications.
  • Further development of polycarbonate-based ocular implants is warranted.